What speakers are you using? Also, if you're thing about the Mesa 2:50, might want to consider the Freyette/VHT. The 20:20 will still be loud, but won't be enough to ever get the JBL's where they need to go. And if you ever end up playing out somewhere besides the bedroom, ala a decent size venue or outdoors, it's never a bad thing to have too much power available.
That said, as Hippieguy stated, throw in a dirt pedal for tone shaping , and it should sound fairly good at lower bedroom volume levels.
Some guys here might tell you to just go for a small Fender combo. I kind of disagree with this, especially for the bedroom player; at home you can set up a real rig and never have to worry about lugging all that shit around, setup/teardown, worrying about drunk spinners next to your 3k setup, etc.. I think If I were a real gigging guitarist and not a mostly weekend warrior, then I would probably just grab a small combo and an M13..
My 2c