I put a CAE Sound Buffer (I have a Waldo buffer in another guitar, both are fine, though for my next Jerry guitar, if there is one, I'll go with a Redeemer) in my S-style axe (the '98 Reverend USA Avenger, pictured below).
For a blaster type effect, I use either the MXR Micro Amp model in my Line 6 M13 or my XTS Pegasus Boost pedal for Blaster-like impact.
Here's my reasoning: I feel the buffer has its maximum positive tonal impacts immediately following the PUPs. Using a buffered pedal (or a pedal buffer) is good for what it is, too, but not quite the same as buffering the signal immediately in the guitar. Whereas I have another guitar with an on-board Blaster I can compare with my two guitars with on board buffers. Based on running the latter two through my M13 or Pegasus pedals, I feel that placing the Blaster in the pedal chain is relatively less impactful than having the initial buffer there.
Hope this helps.