I have the 30 watt version. For me this is what I use. WARNING: I am by no means a Jerry sound expert or claim to be. It is my opinion I can get fairly close with these settings.
I like to use the clean channel with reverb at the high end
Treble all the way up
Bass 1 or less.
Volume knob on amp at 10:00 or more depending on if I am home alone
Volume knob on guitar 9-10
Split coil for Middle super II on my strat and tone knob I play with anywhere between 7 and 10. For me this is the key.
If you switch from the clean setting you can get some nice growl but again I keep the gain at the very minimum and bass at maybe 2. The rest is mostly the same besides adjusting the amp volume.
Hope this helps