Hey all,
This might be an issue I've had for some time but just noticed it this past weekend when hooking up my new SMS Classic preamp. I was using a fairly complicated set up so I plugged it all in and tested it out one step at a time. My rig I'm using now is:
Warmoth WGD - maple & mahogany body, solid rosewood neck - 3 Barden humbuckers - Graph-Tech midi/piezo pickup
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Roland GR 33 guitar synth
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T-Rex Dr. Swamp overdrive
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Haz Mutron III
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SMS Classic Preamp
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Lexicon MPX G2 effects unit
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Mesa Boogie Mark III (power section only - preamp bypassed)
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Mesa 2x12 cabinet
Up to the point I hooked up the Roland GR 33 - I think it was about the best tone I've ever had. When I hooked up the synth I noticed that some of the bottom disappeared and it sounded like a little high end clipping entered the picture. It wasn't horrible or unusable but certainly not as sweet as it sounded before putting the GR-33 in the chain. Prior to connecting it I used the 1/4" output. When I added the GR-33 I used the 13 pin GK cable and ran my signal out of the guitar out in the GR-33.
Here's a sound clip with the GR-33 (I don't have clip of what it sounded like before adding the synth).
http://www.vtcli.com/media/tom/01_Dark_Hollow.mp3
Has anyone had this issue?

