I do use that humbucker.
It warms & fattens the signal, but if you're not just doing Jer...that's just fine. I love to use the HB to push my Earth Drive. I have the ED in a GCX, and in single-coil mode it add's just a bit of grizzle. When you flip the HB on it gets nice & dirty. I love that option.
I don't use it to boost the envelope filter. My MuTron is set for the output of a split Super 2, and quacks perfectly with that setup. If I'm using that effect and switch to the HB, it changes the output pretty dramatically and not in a good way.
For the build I'm into, I'll also add a blaster (in addition to the buffer). I've played with a blaster in another guitar, and now I'm ready to have both on board at all times.
"Hi Ho...the Carrion Crow...FoldeRoldeRiddle"