I have a 2681 (or whichever it is without the vines). I was on a kick of building different preamp designs, so I put one of Craig Anderton's Clarifiers in there. It's basically a buffer with a 2 band EQ built onto a piece of perfboard. It's really tight, but it fits and sounds pretty good, although it has monstrous gain. I also have a Bartolini Hi-A strat pickup in the middle position, closer to the bridge pickup. It sounds really cool, but it's kind of noisy, so usually I stick with the original humbuckers, which are plenty bright.
Very cool guitar that doesn't get much playing time these days (mostly my franken Tele or my '56 ES140T get played).