Not a problem d, happy for your input. If you were starting to sound like Cliff Claven then I'm Reverend Jim, especially when I try to talk theory. I do indeed approach this from an A Mixolydian perspective.
As an extention of that, of sorts anyway, I've found that being more conscious of playing over the chords has opened some other doors. I suppose even though the notes are the same (D ionian and A mixolydian) it's as if I'm changing keys due to being more aware of having my lead have more resonance with the particular chord I'm soloing over.
A simple example of this would be picking out the triad notes of each chord through the progression, which by the way, Mr. Garcia would often do.
This approach also opened doors in terms of workable chromatics. While Franklin's would not be a song suitable for a large dose of chromatics, viewing soloing as switching keys (A to D etc. as stated above) did open up more options for where and how one could sprinkle chromatics.
I can literally play any note while soloing in this song. Now it should be understood that I could not pull off an A# standing essentially by itself, but in a run between A and B while playing over the D chord it is workable. The same would apply for say Ab and Eb among others although the runs that would contain them MAY be exclusive to playing over the A chord OR the D chord but likely not both. F is playable over both between E and F#. Of course I don't mean to imply that chromatics are limited to 3 note runs. I'm limiting for the sake of the discussion. Now I say all this with a grain of salt because depending on how you are approaching these notes almost anything is doable.
Things opened up for me when I broke songs down in this manner.
Now the trick is once these things make sense conceptually, to internalize them and have them flow freely and naturally.
Just like when you begin a sentence, you're really not sure where it's going or the exact way it will manifest, although you do have an idea of what you want to say. You sort of have faith that it will make sense in the end. I approach soloing similarly. It's optimal to "consciously create" your licks but some of my best stuff was while I was "in the zone".
While I've definitely been checking out the tank, I haven't noticed if you've spoken much about chromatics yet. I'll check, but if you haven't, it's a worthy topic. Thanks.