A couple factors to look into going from digital to analog. You probably know this, but if not.
1.) what is your pickup height to the strings? You need the strongest signal you can throw at it, preferably from the pickups and a single coil of either a dual sound or super2 will do the trick if at a workable height.
2.) what is in the chain? Again, the envelope wants the strongest signal. Any buffered pedals in front of it may cause problems. An effect known to cause issues in front of it will be the Boss Oc-2. Think true bypass, effect buffers after can cause issues as well.
"Tone is in the instruments. Technique in the hands. Do what you will." ~quote from some guy at the TGP forum
"Without a doubt, the quality of your instrument will effect your tone, and any pickups, effects, amps, and microphones used along the way will also have an impact on the sound waves."~Cameron Mizell